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Japanese

A HISTOPATHOLOGICAL STUDY ON A GLIOMA WITH RADIATION NECROSIS AND BRAIN STEM SPONGIFORM DEGENERATION Masahiko Taneda 1 , Katsushige Yamashiro 1 , Nishio Nakamura 1 , Toshimitsu Aida 2 1Second Department of Pathology, Hokkaido University School of Medicine 2Department of Neurosurgery, Hokkaido University School of Medicine pp.473-478
Published Date 1982/5/1
DOI https://doi.org/10.11477/mf.1406204938
  • Abstract
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A histopathological study on an autopsy case of 38-year-old female who had suffered from huge glioma and received radiation therapy as well as operation and chemotherapy was reported.

The tumor mainly involved the right frontal lobe and partially invaded to the left cerebral hemisphere. Subarachnoidal dissemination of tumor cells was noticed in cerebellum, brain stem and spinal cord.

Under the microscope the tumor was mainly consisted of astrocytic tumor cells, while oligoden-drocytic ones and those with anaplastic or bizarre nuclei were observed among them. Though epen-dymomatous appearance was partially seen, no true rosette was found. From these findings the tumor was histologically diagnosed as anaplastic glioma.

Simultaneously, there was massive coagulative necrosis which was limited to the irradiated area in the tumor tissue and surely attributable to irradia-tion. In addition, proliferation of gemistocytic astrocytes which was independent of glioma itself was widely observed in the field of irradiation.

Another remarkable finding was spongiform degeneration which was located in the subpial area of brain stem including degenerative products of myelin sheaths and axons with neither inflam-matory changes nor gliosis. In some papers it is suggested that such a lesion has something to do with irradiation or chemotherapy. But in our case this lesion was found in non-irradiated area and no intramedullary injection of chemical agents was performed. Further, the distribution of this lesion was for the most part restricted to the domain of the pontine cistern which had been huge owing to stagnant hemorrhagic fluid. Therefore, it is highly probable that this lesion was caused by the abnormal pia-glial barrier.


Copyright © 1982, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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