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NMR: ITS APPLICATION TO THE EXPERIMENTAL STUDY OF HYDROCEPHALUS AND BRAIN EDEMA Renin Asato 1 , Takaho Murata 1 , Koreaki Mori 1 , Hajime Handa 1 1Department of Neurosurgery, Kyoto University pp.603-609
Published Date 1981/6/1
DOI https://doi.org/10.11477/mf.1406204777
  • Abstract
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The pulsed NMR technique is very sensitive to molecular movement because its observation fre-quency is in the range of the rates of molecular movement. Furthermore it makes it possible to study the interested molecules in the biological tissues physically and noninvasively. In this report we have investigated the experimental brain edema and hydrocephalus, in both of which the tissue fluid changes are main pathology, through 1H-NMR relaxation study of water molecule in the brain tissues. The longitudinal (T1) and the transverse (T2) relaxation times were measured with Varian-HR-220 spectrometer modified with Nicolet-TT-100 PFT system. The experimental materials were the adult male Wistar rats suffering from cold injury edema and the adult canines suffering from kaolin hydrocephalus. The study showed firstly that in brain edema no particular changes were found for relaxation times in the white matter, whereas in the gray matter, discrepancy between the changesof T1 and T2 was observed. That is to say, there were 2 components of T2 in contrast with single T1 value in the same sample of the edematous gray matter, which indicates the existence of 2 fractions of tissue water, not exchanging on an NMR time scale. Secondary, a good correlation between the longitudinal (T1) relaxation time and the tissue water content was found for the dog brains, which suggests that we can analyse the NMR relaxation data of the dog brains based on the two-fraction fast-exchange model.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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