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EFFECTS OF ATP ON CEREBRAL CIRCULATION:MORPHOLOGICAL OBSERVATION OF CEREBRAL BLOOD VESSEL AND CEREBRAL HEMODYNAMICS Hideoki Terada 1 1Department of Neurosurgery, Nara Medical University pp.151-156
Published Date 1976/2/1
DOI https://doi.org/10.11477/mf.1406203840
  • Abstract
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Review was made on the effect of adenosinetriphosphate, 1.0-3.0mg/kg intravenously, on thecerebral circulation and the presence of the dilatingaction on the cerebral blood-vessels in cats.

1. The group of the normal intra-cranial pressureshowed, as reported previously, the transient hypo-tension and its complicated decrease of cerebralblood-circulation at the initial period for 30-100check, then demonstrating the increase of cerebralblood-flow for 200-1000 check. Its increased volumeand duration were dose-dependent.

2. The group of the loaded intracranial pressureof 20-30 mmHg (slightly elevated group) showedthe increase of cerebral blood-flow, like the groupof the normal intracranial pressure. However, theeffect of ATP showed the decrease or disappearancein accordance with the elevation of the loadedpressure.

3. Cerebral vasodilating effect of ATP waspromptly observed after the administration, and itsdegree was 30-50% in photographical observation.

4. Increasing effect on cerebral blood-flow andcerebral vasodilating action of ATP were similarin the pattern to that of vasodilators such aspapaverine hydrochloride.


Copyright © 1976, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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