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Kikuo Kyoi 1 , Kazuhiro Yokoyama 1 , Masashi Tsukamoto 1 , Tetsuya Morimoto 1 , Toshisuke Sakaki 1 , Kazuhiko Kinugawa 1 , Atsuo Okazaki 1 , Shozaburo Utsumi 1 1Department of Neurosurgery, Nara Medical University pp.1145-1151
Published Date 1982/12/1
DOI https://doi.org/10.11477/mf.1406205037

Polygraphycal studies were carried out in order to evaluate the effects of Diltiazem (Ca-antagonist) on cerebral circulation in cats.

In addition to these studies, the inhibitory effect of Diltiazem on incubated blood-, and serotonin-induced vasocontraction of basilar arteries was observed through on operating microscope.

Experimental vasospasm were induced by local administration of incubated blood and 10-5~10-6M serotonin solution. The required dose of Diltia-zem, 30-300 itg/kg, was injected by one shot in-travenously.

CBF slightly decreased concomitantly with tra-nsiently decreased blood pressure shortly after in-travenous injection of Diltiazem. After that, CBF increased for 15-20 minutes and returned to the state similar to that before the administration of Diltiazem.

The changes in reactive pattern of CBF depend on the doses of Diltiazem and related to changes of CAR and VAR which were thought to indi-cate the blood of cardiac output.

Vasocontraction induced by incubated blood and serotonin was released 30-35 per cent for 30 minu-tes after intravenous injetion of Diltiazem 100 lig! kg. However, by administration of Diltiazem be-fore and after local application of incubated blood and serotonin on basilar arteries, vasocontraction was inhibited completely.

These data suggest that administration of Dilti-azem (Ca-antagonist) might be useful in the pro-phylaxis and treatment of vasospasm following rupture of cerebral aneurysm.


Copyright © 1982, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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