アノキシアの冠血行動態におよぼす影響—冠血管の態度を中心として

The Effects of Acute Induced Anoxia on Coronary Circulatory Dynamics:Anoxia and Coronary Vascular Changes

I．緒言

　冠カテーテル法の急速な進歩発達に伴い，冠疾患の臨床的な研究が多数発表されてきた。然し冠血管に病変を有する実験動物を得ることが比較的困難なために，その病態生理学的基礎研究はあまり発表されていない。五島^1）により犬に実験的に冠血管の病変を作り得たので，これを実験対象の一部とし基礎的な実験を行い，併せて臨床的にみられる人の冠硬化症例の検査成績と比較検討した。本論文は低酸素吸入前後の主として冠血行動態の解析であるが，今迄に未発表の方法による冠血液量および冠血管弾性率の研究も含まれている。

In view of studying conditions and changes in the coronary vessels at rest and during anoxia test, the following experiments were done. Coronary sinus catheterization was performed on men and dogs with normal heart and with coronary vascular lesions, and various circulatory dynamics were measured. Special emphasis was laid on the coronary vascular elastance obtained from the pressure curve of coronary sinus and coronary blood flow per beat, and also on the coronary blood volume which was calculated from the dye dilution curve of the blood taken from the coro-nary sinus after the injection of the dye into the left ventricle and from coronary blood flow.

1. At rest, the coronary blood volume of the heart with coronary vascular lesion was not so different from that of the normal heart. But the coronary vascular elastance of the coronary vascular lesion was lessened than that of the normal heart.

2. In anoxia test, marked increase in the coronary blood volume and decrease in the coronary vascular elastance were observed in the normal heart.

In the heart with coronary vascular lesion, the coronary blood volume was increased as much as in the normal heart. The coronary vascular elastance, however, was markedly increased.

3. The coronary vessel, which fell into decompensation on anoxia test, regained compensated state after the cessation of anoxia test and the coronary vascular elastance restored the pre-anoxic state. Therefore, this changes is reversible, within some limits.