クロールプロマジン（注射）による脳波・瞳孔・血圧等の変化の相関について—クロールプロマジンテスト

CORRELATION BETWEEN THE CHANGES OF EEG, PUPILLES AND BLOOD PRESSURE DUE TO INTRAVENOUS INJECTION OF CHLORPROMAZINE:CHLORPROMAZIME TEST

緒言

　クロールプロマジン（以下CPと略記す）投与による各種身体的および精神的症状については，数多くの観察，報告がなされており，こと新しく記載するまでもないことであるが，本剤に対する個人的な差異についてはあまり検討されていない。

　我々が臨床上日常に経験するこの感受性の差異を客観的に評価し，かつその治療上の意義を明らかにすることは重要なことと考えられる。そこで我々は本剤による自律神経症状の変化を主とした指標をえらび，できるだけ簡易に検査し得る方法を検討した。

In order to find quantitatively the individuality (or individual difference) of the most popular neu-roleptics, chlorpromazine, this test was composed.

Chlorpromazine 0. 5 mg/kg was injected intrave-nously to 38 cases of scizophrenic patients, then EEG and various autonomic function were inves-tigated every two minutes for half hour.

In the series of our test α waves in EEG and constriction of pupilles responded most sensitively to CP. and these both kept high correlation.

Among our cases it is found that they made cleary two groups, one was named CP. sensitive group and the other was not sensive, dull group, and they were evidently charactrized as follows. :

Sensitive group : Percent of decrease of a waves< 40% and myosis rate <40%

Dull group : Percent of decrease of a waves> 40% and myosis rate> 40%

These percent of decrease of a waves and myosis rate were made by comparison with the changes after injection of CP. and before.