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STUDY ON THE LONG-ACTING ANTI-EPILEPTIC DRUGS Kenichi KOBAYASHI 1 , Misa TAKAMIZAWA 1 , Teruyoshi KOBAYASHI 1 , Tadashi OTAKA 1 , Hitoshi FUKUZAWA 1 , Ryo TAKAHASHI 2 , Tokuji SUZUKI 3 , Yukiya SAITOH 3 1Department of Neuropsychiatry Tokyo Medical and Dental University 2Department of Psychiatry, The University of Tokyo Faculty of Medicine 3Pharmacy, The University of Tokyo Hospital pp.735-742
Published Date 1969/7/1
DOI https://doi.org/10.11477/mf.1406202565
  • Abstract
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As a first step of the study on long-acting an-tiepileptic drugs, a sustained release-type of diphenyl-hydantoin (SR-D. H.) was made and the change in blood D. H. concentration after SR-D. H. administra-tion in normal persons and epileptic patients, as well as the clinical effect of SR-D. H. on epileptic patients were studied.

1) After one dose of SR-D. H. was administered, blood concentration of D. H. reached higher level than that after the administration of ordinary D.H. powder.

2) Blood concentration of D. H. decreased rapidly after the daily administration of ordinary powder was withdrawn from one epileptic patient, and increased slowly when daily administration was resumed. On the contrary, this concentration de-creased slowly after the withdrawal of daily admin-istration of SR-D.H., and iucreased rapidly when daily administration was resumed.

3) With SR-D.H., either marked or moderate improvements were seen in four out of five subjects who had epilepsies which were difficult to cure with ordinary anti-epileptic drugs.

4) As for the side effects no difference was ob-served between ordinary D. H. powder and SR-D.H.

In view of these findings a reasonable drug treat-ment of epilepsy was discussed.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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