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Brain and Nerve No to Shinkei Volume 20, Issue 12 （December 1968）

Brain and Nerve 脳と神経 20巻12号（1968年12月発行）

Japanese English

研究

X線照射の脳組織呼吸および蛋白質，核酸代謝に及ぼす影響について EFFECTS OF X-IRRADIATION ON THE PROTEIN METABOLISM OF BRAIN 原隆夫 ¹ Takao HARA ¹ ¹新潟大学脳研究所脳神経外科学教室 ¹Departments of Neurosurgery, Brain Research Institute, Niigata University pp.1287-1294

発行日 1968年12月1日 Published Date 1968/12/1

DOI https://doi.org/10.11477/mf.1406202481

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Abstract 文献概要
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I．緒言

　放射線が生体に重大な影響を及ぼすことは周知の事実であり，特に増殖過程にある細胞や組織の放射線に対する感受性が高いことは古くから認められている。このような放射線の作用は，異常な発育を遂げる悪性腫瘍の治療に利用されており，脳腫瘍に対しても，手術療法に限界のあることと相俟つて，照射療法のみが行なわれることも多く，また手術後療法としてもしばしば用いられている。しかしこの場合に発現する中枢神経系の障害や，全身的な副作用は照射療法上大きな難点となっている。照射療法に際し，腫瘍部位以外の脳部分，さらに全身にも代謝的な変化が惹起されることが考えられるが，このような観点からの生化学的な研究はごくわずかしかなされていない。本論文では，X線照射の脳ならびに全身におよぼす影響を蛋白質代謝と組織呼吸，さらに核酸代謝の面から検索した。

The effect of X-irradiation on the protein meta-bolism of adult rat brain was studied and the results were compared with those of liver and spleen.

(1) The head X-irradiation, single dose irradiation of 3,000 r or divided dose irradiation of 500 r daily for six days, markedly inhibited the in vitro amino acid incorporation into proteins not only of brain slices but also that of liver slices. In case of divided dose irradiation the reduction in the incorporation shown at the later stage was preceded by an increase at the early stage of X-irradiation in all tissues in marked contrast to the rectilinear reduction obser-vable after the single dose irradiation.

(2) The whole body irradiation, 600 r daily for two days, did not inhibit but rather stimulate the in vitro incorporation of amino acid into the proteins of rat brain, liver and spleen slices. But after four day irradiation of 300 r per day, marked reduction in the incorporation was observed in all tissues. On the 30 th day after single dose irradiation of 500 r decreased incorporation was observed only in brain slices.

(3) In in vivo experiment, in which ¹⁴C-labelled amino acid was given intracisternally after the six day head irradiation (500 r per day), marked inhibi-tion in the incorporation into the rat brain protein was shown.

(4) It was suggested that there might be some intimate relationship between brain and liver with regards to the protein metabolism.

(5) Almost unchanged oxygen consumption and nucleic acid metabolism observed in the present ex-periment failed to give any explanation for the above mentioned effect of X-irradiation on the pro-tein metabolism.