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The Effect of the Right Ilemithoracic Irradiation on the Penetration of CAZ into the Alveolar Space in Rats Masahiro Imamura 1 , Takashi Murata 1 , Reiko Nasu 1 , Yuzhou Fujii 1 , Hiroyuki Kimura 1 , Mikio Akai 1 , Kiyoshi Akagi 1 , Yoshimasa Tanaka 1 1Department of Radiology, Kansai Medical University Keyword: 放射線肺炎 , 薬剤透過性 , 気管支肺胞洗浄 , radiation pneumonitis , penetration of CAZ , bronchoalveolar lavage (PAL) pp.1225-1229
Published Date 1997/12/15
DOI https://doi.org/10.11477/mf.1404910083
  • Abstract
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The effect of irradiation on the transfer of antibioticto the pulmonary tissue was examined in the period after irradiation using a unilateral lung irradiation model in rats. The results showed the following: 1) Both transfer of CAZ from blood to the lung tissue, i.e., the permeability of pulmonary capillary epithelium, and transfer of CAZ from the lung tissue to BALE, i.e., the permeability of the alveolar epithelium were found to reach the maximum 4~5 weeks after irradiation. 2) In the time-course changes of the absolute amount of CAZ in the lung tissue, the amount in the control lung as well as that in the irradiated lung increased significantly from 3 days after irradiation onward when compared with control animals. Regarding the transfer of antibi-otics to the lung tissue, the changes in the lung of the non-irradiated side as well as that in the irradiated side were observed. These results suggest that the effect of irradiation may have been transmitted to the non-irradiated region by means of an immunological mecha-nism or some intracellular transport system caused by,for example, changes occurring at the alveolar level shortly after irradiation.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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