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ON THE HYPOTHALAMIC OBESITY INDUCED BY GOLDTHIOGLUCOSE:Experimental Studies on the Neural Control of Obesity (I) Atsuyoshi MORI 1 1Dept. of Neuropsychiatry, Toho University School of Medicine pp.962-969
Published Date 1967/10/1
DOI https://doi.org/10.11477/mf.1406202285
  • Abstract
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Inbread CBA female mice (80-90 days old of age, 19-22 g. of body weight) were parenterally given a dose of 0.4 mg/g/b. w. of goldthioglucose (GTG) that results in obesity. Studies of food intake in 8 mice treated with GTG showed 40-50% increase in foodconsumption for about 4 weeks (from the second to the fifth week after treatment). The accompanying slight increase in water intake was seen during the above-mentioned periods. The GTG-treated mice showed 94% of weight gain 13 weeks after treatment and it was in marked contrast to that of the controls.

Histological studies on the brains of 6 GTG-treated mice showed the bilateral damage in the ventromedial "satiety center" of hypothalamus and also, in the preoptic region, medula oblongata, doral hippocampus, dentate gyrus, fornix and septum.

These results show that GTG is a good experi-mental tool for the studies on the hypothalamic obe-sity or the neural control of obesity.


Copyright © 1967, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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