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Japanese

EFFECTS OF SHORT CHAIN FATTY ACID ANIONS ON THE ELECTRICAL ACTIVITY OF NEO-, PALEO-, AND ARCHICORTICAL SYSTEMS Yasutoshi MUTO 1 , Yoshiyata TAKAHASHI 1 , Hiroshi KAWAMURA 2 1The 3rd Dept. of Internal Med. Faculty of Med. Univ. of Tokyo 2The 2nd Dept. of Physilolgy, Yokohama Prefectural Univ. School of Med. pp.601-608
Published Date 1964/7/1
DOI https://doi.org/10.11477/mf.1406201672
  • Abstract
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The effects of short chain fatty acid anions (SCFA), including n-butyric, n-, i-valeric and n-caproic acid, upon the electrical activities of the neo-, paleoa, and archicortical systems were observed in 35 unanesthe-tized amd Flaxédil immobilized cats under artifieial respiration, and the following results were obtained;

1) The deep sleep patterns of the high amplitude slow waves with spindle bursts on the neocortex were induced immediately after the intravenous in-jection of 2~4mM/kg of SCFA and persisted from 40 seconds to about 60 minutes, while the electrical activities of the limbic systems (the amygdala and hippocampus) were decreased to a lesser extent than that of the neocortex and then the manifest dissocia-tion of the electrical activities between the neocortex and limbic cortices was observed; that is characteris-tic of the EEG changes by the administration of SCFA.

2) The bilaterally synchronous spiky waves or triphasic waves (4~5 c/s) were observed solely on the neocortex.

3) In the midpontine pretrigeminal transected preparations, cutted-off the most of the peripheral impulses, were also decreased the electrical activities of the neocortex and then the same dissociation of the EEG changes between the neocortex and limbic cortices was also observed by the injection of SCFA.

4) The evoked potentials of the midbrain reticular formation by the contralateral sciatic nerve stimula-tion were strongly suppressed in amplitude without any remarkable changes of the neocortical potentials.

Taking these results into consideration, it may be conclude that SCFA mainly suppress the midbrain-neocortical reticular activating systems.


Copyright © 1964, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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