雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

A TYPICAL CASE OF THROMBOTIC THROMBOCYTOPENIC PURPURA (T. T. P.) Shizuo KAJI 1 , Torahiko KON 2 1Dept. of Psychiatry Niigata Univ. School of Medicine 2Dept. of Pathology, Brain Research Institute Niigata Univ. School of Medicine pp.403-408
Published Date 1964/5/1
DOI https://doi.org/10.11477/mf.1406201638
  • Abstract
  • Look Inside

On Sept. 6, 1962, a 52 year old office-man was admitted to the hospital with the chief complaints of transiently repeated unconsciousness and motor disturbances. His parent and 3 among 9 sibs had died of apoplexia. At the age of 29 years he had had blast injury, being partially paralysed on the right upper limb. Four years prior to admission he had undergone segmentary pulmonectomy (S1+2, S3) on the left and the next year exstirpasion of right upper lobe, owing to pulmonary tuberculosis. Three weeks before he first noticed general tiredness, nausea and numbness of his right hand. Two days before he had a transient attack of right hemiplegia and dysphasia. On admission he was delirious and icteric and multiple ecchymoses were present on the axillae, chest wall and upper limbs. A probable diagnosis of T. T. P. was made, owing to transient neuropsychiatric symptoms, hemorrhagic diathesis and blood findings (anemia 231 millions, thrombocytope-nia 60,000, prolonged bleeding time and normal coagulation time). Gradually the condition becoming worse, he expired under status epilepticus on 7th hospital day.

The postmortem histological examination disclosed multiple hyaline thrombus formation in the arterioles of various organs (Of marked degree in the brain, spleen, heart, kidneys, adrenals, pancreas, neurohypo-physis etc. Of moderate degree in the stomach intestine, testes, bone marrow etc. Of slight degree of absent in the lungs, liver, prossate tongue, sali-vary glands, lympnodes etc.). The thrombus was adherent to the vessel wall on one side, accompanied by subinitimal fibrinoid degeneration and on the opposit side the wall became enlarged by aneurysma formation. Megacaryocytes were abundant in the bone marrow and also in the lung capillaries.

The clinical symptoms have been explained from pathological findings and the pathogehesis of T. T. P. has been discussed, being compared with collagen diseases.


Copyright © 1964, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

関連文献

もっと見る

文献を共有