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STUDIES ON THE AMMONIA-BINDING MECHANISM IN THE BRAIN TISSUE INFLUENCED BY THE REPEATED ELECTRICALLY INDUCED CONVULSIONS Seinen Matsumura 1 1Department of Neuropsychiatry, Faculty of Medicine, Kanazawa University pp.519-534
Published Date 1960/6/1
DOI https://doi.org/10.11477/mf.1406200939
  • Abstract
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These experiments were made for the pur-pose of studying the ammonia binding mec-hanism in the brain tissue of a guinea pig the functions of which were disturbed by me-ans of the repeated electric convulsions.

The electrical convulsions were applied on two groups of adult guinea pigs; 1st group on which the electrical convulsions were re-peated less than 50 times, while 2nd group more than 50 times.

The results obtained by measuring the am-monia formation and the oxygen uptake of the respective brain slices suspended in Kre-bs Ringer phosphate saline which contained glucose, pyruvate, glutamate or α-ketogluta-rate as substrate, were as follows.

1) The oxygen uptake by the normal gui-nea pig brain slices is the greatest in the presence of glutamate as substrate, and as to the other substrates the order of the gre-atness is: pyruvate, α-ketoglutarate, glucose.

The ammonia formation by that is the greatest in the absence of substrate. Ammonia formation in the presence of α-ketoglutarate, suppressed at the beginning of incubation,is observed in a short time.

When glucose, pyruvate or glutamate are added as substrate, ammonia formation is clearly suppressed.


Copyright © 1960, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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