精神疾患主に精神分裂病の循環血液量について

CIRCULATION BLOOD VOLUME OF CASES OF MENTAL DISEASES WITH SPECIAL REFERENCE TO SCHIZOPHRENIA

I．緒言

　精神疾患における水分及び電解質代謝に重要なる意義を有する循環血液量の検索は，身体的諸条件との関連については比較的多くなされているに対して，精神的諸条件については殆んど検討されていない。我々は教室同僚諸氏と共に電解質代謝の研究に従事しつつあるが，其等の変動の起因を考察する一端として循環血液量の検索を必要とし，此処に本研究を企てた次第である。もつとも教室の橋本^6）は精神疾患の水分代謝研究の一部として循環血液量を測定しすでに報告したが，我々は更にそれを推し進めて精神分裂病を主として，精神病像との関連について詳細に検討せんと試みた。

We have measured circulation blood volu-mes of patients with various mental diseases-and particularly with schizophrenia by the-use of the Evans-Blue method. The patients. consisted of 135 cases of schizophrenia, 6 ca-ses of mania, 5 cases of depression, 5 cases-of senile mental diseases, 6 paralytic cases, 2 cases of alcoholism and 1 case of epilepsy. Twenty healthy persons were used as a con-trol group.

1. In a group of cases of schizophrenia the circulation blood volume, the circulation blood plasma volume, the circulation hemato-cyte volume and the hematocrit value lay in nearly normal ranges on the average for both sexes, but the variations of these valu-es were great as compared to those of the, control group.

2. Fresh cases of schizophrenia gave high-er values than old ones. Though the varia-tions of these values were great, no signifi-cant difference was detected between these cases. It was shown that the circulation blood volume, the circulation blood plasma volume, the circulation hematocyte volume and the-hematocrit value of the same patient showed a greater decrease in the convalescent stage than in the stage of the diseaes.