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EFFECTS OF DRUGS ON BRAIN EXCITABILITY AND THE RECOVERY TIME FOR SEIZURE Toshio Nasu pp.505-518
Published Date 1960/6/1
DOI https://doi.org/10.11477/mf.1406200938
  • Abstract
  • Look Inside

The neurochemical mechanisms concerned in changing brain excitability are of impor-tance for the understanding of seizure patho-physiology.

Changes in rat brain excitability following two week drug administration were measured using the electroshock threshold (EST) and maximal electroshock seizure (MES) duration techniques by the modified Woodbury's appa-ratus.

Effect of the acute administration of drugs on the refractory period of mice following the MES and EST were also measured. As a measure of the refractory period of animals was used the recovery time 50(RT50), which is, according to Woodbury, defined as the time required, after an initial electroshock seizure, for 50% of animals to recover to the extent that a second electroshock seizure can be elicited. The RT50 for MES and EST of mice was respectively 84 seconds and 15.1 minutes.

1) In the animals given ACTH, the EST was elevated, the duration of the tonic exten-sion phase of MES shortened and the reco-very time for EST hastened.

2) In the animals given hydrocortisone, the EST was lowered, the duration of MES pro-longed and the RT50 for EST hastened.


Copyright © 1960, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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