進行麻痺に対するLeocillin使用知見

STUDIES ON THE LEOCILLIN (BENZYLPENICILLIN β-AMINOETHYL-ESTERHYDROIODIDE) TREATMENT FOR THE GENERAL PARESIS

I．はしがき

　神経梅毒のPenicillin （以下Pcと略記）治療は中枢神経の炎症過程を出来るだけ早く完全に消褪させ，その代償不能な神経組織崩壊を，最小限度に喰い止める事にある。その為には出来るだけ多くのPc量を撰択的に脳脊髄組織及び髄液へ移行させる事が望ましいと考え，今迄吾々は是を凡そ次の4つの方法に分け研究して来た。

　即ち，

The purpose of penicillin treatment of neurosyphilis consists in checking the development of the inflammatory process as completely as possible and keeping the nervous tissue from destruction as little as possible.

For this purpose, we have up to this time pursed our studies, thinking it is desirable to transmit the penicillin selectively to the brain tissue and the cerebrospinal fluid, and we came to the conclusion that this purpose can only be accomplished by changing the chemical construction of penicillin itself.

We have tried the Leocillin alone therapy (total dosis 1,200,000 units, and 500,000 units for one day administered intramusculary) on ten patients of general paresis and watched the follow up for a little more than one year.

We also compared this results with that obtained from malaria alone therapy and malaria-penicillin treatment.

The results showed that the Leocillin alone therapy excelled in the cell count and the colloidal reaction than malaria alone therapy, and that it was about equally as good as in the case of penicillin-malaria treatment.