血管造影剤の脳に及す影響の脳波的組織学的研究

Electroencephalographic and Histologic Study of Cerebral Angiography

緒言

　脳血管撮影は頭蓋内疾患の診断にとつて甚だ有用な方法であり，今日では多く行われ，摂影前に沃度過敏症に対する予備試験を行つて居るが，それにもかゝわらず痙攣，半身麻痺，死亡等の重篤な副作用を伴い，此れは多くの人によつて報告され，吾々も1死亡例を経験して居る。又常に激裂な頭痛を伴うものである。此等を予防したいと云う考えから脳血管撮影が脳に及す影響を脳波的に，又組織学的に動物実験によつて検査した。

Changes of E. E. G. by cerebral angiography are spikes, decrease of amplitude and 8 wave. Histologic changes are edema, petechiae, blee-ding, congestion, acute edema of nerve cells and glia cells, and gliosis.

Amipan, Isomital inhibit spikes,but have no effect on decrease of amplitude and S wave. Other narcotics have no effect on E. E. G.

Every narcotica and hypnotica have no effect on histological changes.

Methobromin has a little effect on inhibition of spikes, but decrease of amplitude and δ wave are not influenced.

Other depressors or vasodilatators have no effect on changes of E. E. G.

Histological change are least by methobromin or novocain block of the cervical sympathetic nerve. Other depressor have no effect on his-tological changes.