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【抄録】頭部CTで右尾状核に限局した虚血病変がみられ,発症後4年半にわたり著明な行動障害を示した症例(男性,31歳)を報告した。行動障害は脱抑制(急性期)から無為(慢性期)へと変化した。また,本症例は日常生活の決まりきった行動以外には柔軟に対処できなくなった。頭部SPECTでは右尾状核と右前頭葉底部の血流低下を認め,行動障害と前頭葉の機能低下との関連が示唆された。一方,神経心理学的検査では知能,記憶や“前頭葉機能”の障害は軽度だったので,検査成績と日常生活の行動障害との関係は単純ではないと考えた。さらに本症例の行動障害をSupervisory AttentionalSystem(Shalliceら,1991)の障害の観点から検討した。
We here report a 31-year-old man showing persistent marked behavioral disorders associat-ed with a small low density area in the head of the right caudate nucleus on CT scan. In the acute stage, he exhibited disinhibition, and then gradually became apathetic. While not able to cope with non-routine activities in daily life, his performance on neuropsychological testing for intelligence, memory, and “frontal lobe function” showed only mild deficit. SPECT scan revealed hypoperfusion involving the right frontal base as well as the right caudate nucleus, suggesting that his behavioral changes were due to extensive damage to both of these regions.
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