A Case of Survival from Severe Non-Cardiac Pulmonary Edema Caused by a Non-Ionic Contrast Media Kaoru Ono 1 , Masahiko Haraguchi 1 , Masahiro Kimura 1 , Kohzo Fujii 1 , Masunori Matsuzaki 1 1Second Department of Internal Medicine, Yamaguchi University School of Medicine Keyword: 非心原性肺水腫 , 非イオン性造影剤 , drug-induced lymphocyte stimulation test(DLST) , non-cardiogenic pulmonary edema , nonionic contrast media pp.193-197
Published Date 2000/2/15
DOI https://doi.org/10.11477/mf.1404902048
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A 68-year-old man, who had had replacement of hisheart valves and chronic obstructive pulmonary disease, suffered from non-cardiogenic pulmonary edema induced by a non-ionic contrast media. He was admittedto our hospital because of acute exacerbation of hischronic obstructive pulmonary disease. Because he alsohas hepatitis type C, computed tomography wasexamined, indicating hepato-cellular carcinoma. Angiography was performed and cartinostatics were administered via the hepatic artery. About two hours afterIomeprol was infused intravenously, the patient, feltintolerable dyspnea immediately and intubation wasneeded. Chest roentgenogram revealed butterfly shadowspread on the upper lung field bilaterally but the cardiothoracic ratio did not change. We diagnosed the illnessas non-cardiogenic pulmonary edema caused by Iomeprol, because the drug-induced lymphocyte stimulationtest (DLST) showed Iomeprol to be 234%. Steroid pulsetherapy was effective. Our conclusion was that we needto be careful when using non-ionic contrast media aswell as when using ionic-contrast media.

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