MRI造影剤により生じた非心原性肺水腫の1救命例

Non-cardiogenic pulmonary edema after the use of MRI contrast media

ガドリニウム造影剤による造影MRIは，病巣の評価や治療方針の決定において重要な役割を果たす。CTで用いられるヨード造影剤に比べ副作用頻度が少なく比較的安全とされるが，ごくまれに重篤な副作用を引き起こす。今回我々はMRI造影剤であるガドブトール（ガドビスト^®）による重篤な非心原性肺水腫を経験したので，我が国初の報告として文献的考察を加えて報告する。

A 42-year-old woman with lower arm numbness was evaluated with gadobutrol-enhanced magnetic resonance imaging（MRI）of the cervical spinal cord. Thirty minutes after the MRI, the patient developed respiratory difficulty. She had mechanical ventilation for pulmonary edema by adverse reaction of MRI contrast media and was discharged without complications on day 48. Pulmonary edema induced by gadobutrol has not been previously reported in Japan. If such adverse reaction occurs, patients can be saved by prompt and appropriate treatment.