雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Cardiovascular Effects of Rapid Intravenous Administration of ATP in Man Tetsuro Toeda 1 , Tsutomu Miida 1 , Hirotaka Oda 1 , Kazuyoshi Takahashi 1 , Keiichi Tsuchida 1 , Shyuji Suetake 1 , Norio Higuma 1 1Department of Cardiology, Niigata City General Hospital Keyword: アデノシン三リン酸 , 血行動態 , 発作性上室性頻拍 , adenosine triphosphate , hemodynamics , paroxysmal supraventricular tachycardia pp.181-185
Published Date 1999/2/15
DOI https://doi.org/10.11477/mf.1404901849
  • Abstract
  • Look Inside

Adenosine triphosphate (ATP) is the drug of first choice to terminate paroxysmal suprayentricular ta-chycardia such as atrio-ventricular (AV) nodal or AV reentry. ATP must be intavenously injected in a bolus because of its short half-life. However, the hemodyna-mic changes after the intravenous administration of ATP have remained unknown. The present study evalu-ates the hemodynamic effects of ATP in 10 patients with variant angina. who underwent diagnostic cardiac cath-eterization. Systemic arterial pressure was measuredfrom the aorta through a pig-tail catheter inserted via the right femoral artery. A balloon-tipped flow-directed thermodilution catheter was introduced through the right femoral vein to the pulmonary artery to measure cardiac output and pulmonary arterial pressure. The recording of the His bundle electrocardiogram was accomplished by the passage of a tripolar catheter from the right femoral vein. Blood pressure and heart rate respectively showed biphasic changes. Immediately after ATP administration. systolic blood pressure in-creased from 141±22 mmHg to 151±23 mmHg and, 48±13 seconds later, it decreased markedly to 106±18 mmHg. R-R interval on the electrocardiogram was first Prolonged from 865±192 msec to 945=189 msec and. 59±11 seconds later, it was reduced to 736±144 msec. A -H interval on the His bundle electrocardiogram became longer 42±9 seconds after the administration of ATP. There were no significant changes in cardiac output or pulmonary arterial pressure. An increase in systolic blood pressure and R-R interval was associated with direct effects of ATP on the heart, such as the sinus node and the coronary artery. A decrease in systolic blood pressure was induced by vasodilation of the peripheral vessels and then heart rate was increased clue to baroreceptor-mediated vagal withdrawal. It is impor-tant to understand these hemodynamic changes. when the intravenous administration of ATP is performed to terminate paroxysmal supraventricular tachycardia.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

関連文献

もっと見る

文献を共有