Japanese

Modulation of ATP-sensitive Potassium Channels on Coronary Vasculature Mitsuaki Chujo 1 , Hidezo Mori 1 , Etsuro Tanaka 1 , Akihiko Yamakawa 1 , Minhaz Uddin Mohammed 1 , Hiroyasu Sakamoto 1 , Syuichi Haruyama 1 , Yoshiro Shinozaki 1 , Hiroe Nakazawa 1 , Haruka Okino 1 1Department of Physiology, School of Medicine, Tokai University Keyword: 交感神経 , 冠血管抵抗 , ATP感受性Kチャネル , sympathetic nerve , vascular resistance , ATP-sensitive potassium channel pp.893-898
Published Date 1994/9/15
DOI https://doi.org/10.11477/mf.1404900927
  • Abstract
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We examine whether ATP-sensitive potassium (KATP) channels on coronary vascurature and the car-diac sympathetic nerve system modulate coronary vas-cular resistance and the overflow of neurotransmitters at rest and during adrenergic stimuli in a vagotomized condition. Under β-receptor blockade, the KATP, chan-nel blocker, glibenclamide, increased coronary vascular resistance at rest, and enhanced the increase in coro-nary vascular resistance induced by ventrolateral car-diac nerve stimulation (2 to 20 Hz).


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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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