組織酵素抗体法にて確認しえたアミラーゼ産生肺癌の1例

A Case of Amylase Producing Lung Cancer

　血清，尿中ならびに胸水中のアミラーゼ高値を呈し，抗人唾液腺アミラーゼ抗体を用いた酵素抗体法による胸水中の腫瘍細胞内にアミラーゼの局在性を証明しえた肺癌の1症例を経験した．症例は72歳男，咳嗽にて受診し胸部X線写真にて右下肺野に異常陰影を認め，血清アミラーゼ高値のため精査目的で入院．喀痰細胞診にて腺癌と診断．化学療法にて腫瘤縮小と平行して血尿アミラーゼ活性は低下した．その後，脳転移，胸水出現に伴いアミラーゼ活性は再び上昇した．組織酵素抗体法により胸水中腫瘍細胞内にアミラーゼ局在性を証明しえた．

The patient was a 72-year-old man, who was admit-ted to our hospital because of cough. Chest X-rays showed a mass shadow in the right lower lung field. Amylase activities in serum and urine were extremely high. Amylase isozyme pattern identified salivary type amylase. Cytological examination of the sputum sug-gested adenocartinoma. Amylase activities in serum and urine gradually decreased with the administration of chemotherapy. Afterwards, pleural effusion in-creased, and the amylase activity in pleural fluid was also extremely high. Pleural fluid also showed adenocarcinoma.