CA 125の測定が有用であった心嚢液貯留の3例

Serum CA 125 Measurement is Useful in 3 Cases with Pericardial Effusion

　今回我々は，心嚢液貯留例において卵巣癌関連抗原CA125の測定が病態の把握に有用であった3例を経験し，CA125測定の臨床的有用性を検討した．症例1は，19歳男性，心タンポナーデにて入院．入院時中等度の心嚢液貯留とともにCA125も上昇し，各種治療に抵抗し収縮性心膜炎となり，心膜剥離・切除術施行．術後CA125は正常化し，再発は認めず経過良好である．症例2は，心膜中皮腫の50歳男性，入院時心嚢液貯留とともにCA 125は上昇．心嚢液ドレナージにて一時軽快しCA125も低下したが，病勢の悪化とともにCA125は上昇し，再び限局性心嚢液貯留が観察された．症例3は慢性心嚢液貯留の78歳女性，CA125は正常で心嚢液ドレナージにて軽快．再貯留は認めなかった．以上より，CA125測定は心嚢液再貯留に関係し，経過観察するうえで有用な指標と考えられた．

Previously we reported that serum CA 125 level is elevated in cases of pericardial effusion. We report three cases in which serum CA 125 measurement is useful for assessing clinical status.

In case 1, a 19-year-old came to our hospital for cardiac tamponade. Moderate degree of pericardial effusion and high CA 125 level were observed. After the pericardectomy the serum CA 125 level was normalized and pericardial effusion disapeared. Case 2, a 50-year-old man with mesothelioma and in whom serum CA 125 level was elevated with pericardial effusion. After cardiac drainage his condition improved, with de-creased CA 125 level.