The Acute and Chronic Effects of Bunazosin on Exercise Capacity Estimated by the Anaerobic Threshold in Patients with Chronic Congestive Heart Failure Yasuhiro Kawagoe 1 , Hirotaka Kimura 1 , Noboru Kaneko 1 , Tetsuya Sumiyoshi 1 , Hirotaka Nagashima 1 , Shinichi Kimata 1 , Saichi Hosoda 1 , Kimio Konno 2 , Nobuhiro Miki 3 1Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical College 2Department of 1st Medicine, Tokyo Women's Medical College 3Department of 2nd Medicine, Tokyo Women's Medical College Keyword: 慢性心不全 , 塩酸ブナゾシン , 嫌気性代謝閾値 , chronic congestive heart failure , bunazosin hydrochloride , anaerobic threshold pp.1109-1114
Published Date 1992/11/15
DOI https://doi.org/10.11477/mf.1404900574
  • Abstract
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To study the effect of bunazosin on exercise capacity in patients with congestive heart failure (NYHA Ⅱ-Ⅲ), anaerobic thresholds (AT, V02, ml/min/kg) were measured before (control) and after initial 1=2mg administration of bunazosin (acute phase ; N=14) and after two weeks of bunazosin therapy (3mg/day, 1mg t. i. d., chronic phase ; N=6). AT were determined by Wasserman's V-slope method during ergometer exer-cise test with a ramp loading (10 watt/min). AT in-creased significantly from control during both acute (14.2±2.7 to 16.9±3.6 ml/min/kg p<0.005) and chronic (13.6±2.5 to 16.7±1.0 p<0.05) phase.

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