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The role of protein kinase C in left ventricular relaxation impaired by global ischemia Hiroyuki Sonoki 1 , Yasumi Uchida 1 , Takanobu Tomaru 1 , Tsuneaki Sugimoto 1 1Second Department of Internal Medicine, Faculty of Medicine University of Tokyo pp.669-674
Published Date 1989/6/15
DOI https://doi.org/10.11477/mf.1404205496
  • Abstract
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The role of protein kinase C (C kinase) in the left ventricular relaxation impaired by global ischemia was investigated in anesthetised dogs. Left ventri-cular global ischemia model was made by coronary blood flow reduction and atrial pacing (100-180 beats/ min). By this maneuver, the time constant T and left ventricular end-diastolic pressure (LVEDP) were increased in a pacing-rate dependent manner. Intra-coronary infusion of H-7, an inhibitor of C kinase, suppressed the magnitudes of the increments of T and LVEDP, while intracoronary infusion of 12-0-tetrad-ecanoyl-phorbol-13-acetate, an activator of C kinase, enhanced the increases of T and LVEDP caused by ischemia. In non-ischemic group, H-7 did not influen-ced T and LVEDP. The results indicate that C kinase is activated by myocardial ischemia and enhances impairment of left ventricular relaxation.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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