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High energy phosphates and mitchondrial respiratory function after 24 hours cardiac preservation:Comparison between simple hypothermic immersion and continuous hypothermic perfusion Mamoru Tago 1 , Shingo Seno 1 , Ko Bando 1 , Hiromichi Teraoka 1 , Yoshimasa Senoo 1 , Shigeru Teramoto 1 12nd Department of Surgery Okayama University Medical School pp.61-63
Published Date 1989/1/15
DOI https://doi.org/10.11477/mf.1404205403
  • Abstract
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Cardiac preservation is one of the most impor-tant step during heart transplantation. Prolonged preservation period is necessary to get the greater donor pool.

To get safe prolonged preservation two methods, simple hypothermic immersion method (group A) and continuous hypothermic perfusion method (group B), were compared in this report by evaluating the my-ocardiac high energy phosphate level and mitchon-drial respiratory function.

The values of ATP, TAN and Energy charge were significantly higher in group B than group A (p<0. 001). Mitchondrial respiratory function such as state 3 QO2, state 4 QO2, RCI and ADP/O also showed significantly higher values in group B than group A (p<0. 001).

These date indicate that continuous hypothermic perfusion method provides better preservation than simple hypothermic immersion method for 24 hours cardiac preservation.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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