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Japanese

Clinicopathological studies on myasthenia gravis and thymus Tadahiko Kawaguchi 1 , Akio Tani 1 , Hisaaki Koie 1 1The 1st Department of Surgery, Hirosaki University School of Medicine pp.1101-1104
Published Date 1988/10/15
DOI https://doi.org/10.11477/mf.1404205344
  • Abstract
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In this study, we investigated the relationship between myasthenia gravis and thymus. We trans-planted the thymus with myasthenia gravis in nude mice and examined the possibility of occurrence of myasthenia gravis in nude mice. In the electrical testing we observed waning phenomenon in nude mice, but we did not observe the symptom of my-asthenia gravis in nude mice. The transplanted thymus changed into degenerations and necrosis.

On the other hand, we injected the plasma of my-asthenia gravis into nude mice. But in the electrical testing, we did not observe waning phenomenon in nude mice.

Prethymectomy plasma exchange reduced anti-acethylcholine receptor antibody titer and occurrence of postoperative crisis. We concluded that prethy-mectomy plasme exchange was effective for the post-thymectomy management.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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