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Japanese

Effect of Diltiazem on Experimental Cerebral Vasospasm:In comparison with effects of cinnarizine, verapamil and nifedipine Takuji TAKAGI 1 , Hidekazu FUKUOKA 1 , Ken KAMIYA 1 , Hajime NAGAI 1 , Ken HOTTA 2 1Department of Neurosurgery, Nagoya City University Medical School 2Department of Physiology, Nagoya City University Medical School Keyword: Cerebral vasospasm , Ca2+antagonists Diltiazem pp.605-611
Published Date 1983/6/10
DOI https://doi.org/10.11477/mf.1436201683
  • Abstract
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The contractile activity of arterial muscle cells is controlled by the interacellular free Ca2+ concentration. The membrane systems of both the cell surface and internal organs, seem to be responsible for controlling the myoplasmic Ca2+-level. The mechansim of action of Ca2+ antagonists, typified by verapamil and nifedi-pine, has been postulated to be a blockade of trans-membrane calcium influx.

In this study, the vasodilating effect of diltiazem on experimental cerebral vasospasm in vivo was exam-ined using dogs and was compared with those of cinnarizine, verapamil and nifedipine which have already been reported by us.


Copyright © 1983, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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