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Study on Pulmonary Functions of α1-Antitrypsin Mild Deficiency Cases (PiMZ) Masayuki Kambe 1 , Kazuko Kawamura 1 , Tokuo Tsubokura 1 , Mitsuhide Hiramoto 2 , Takashi Kobayakawa 2 , Yukio Nishimoto 2 , Charles Mittman 3 1Department of Clinical Pathology, Hiroshima University, School of Medicine 2Department of Internal Medicine, Hiroshima University, School of Medicine pp.1217-1220
Published Date 1983/11/15
DOI https://doi.org/10.11477/mf.1404204340
  • Abstract
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 Laurell and Eriksson published the first report indicating that α1-antitrypsin deficiency predisposed to the development of COPD.

 In the purpose of early detection on the disturbances of pulmonary functions in α1-antitrypsin mild deficiency cases, the pulmonary functions of 11 α1-antitrypsin mild deficiency cases (PiMZ) were compared with those of normal cases (PiMM).

 The marked results are as follows.

 1) The parameters of flowvolume curves in PiMZ cases were disturbed more than those of PiMM cases.

 2) Volumes of isoflow are specially different between PiMz and PiMM cases.

 3) Mechanical properties like lung work of breathing in PiMZ cases were larger than those in PiMM cases.


Copyright © 1983, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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