Embolic pneumopathy induced by tissue thromboplastin Hiroshi Hasegawa 1 , Hiroshi Nagata 1 , Toshio Murakoshi 1 , Masao Yamauchi 1 , Yutaka Oguma 1 , Tsukasa Seya 1 , Makoto Murao 1 1The First Department of Medicine, Hokkaido University School of Medicine pp.491-496
Published Date 1980/5/15
DOI https://doi.org/10.11477/mf.1404203565
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Rabbits received 25 mg/5 ml of NaCl of tissue thromboplastin. A systematic ultrastructural study was carried out after 10 sec., 1 min., 5 min., 24 hrs, 48 hrs and 1 w. 5 min. after injection of tissue thromboplastin, capillaries were obstructed by recent thrombi formed of fibrin or fibrin-platelets. As early as 24 hrs, capillary obstruction had disappeared. In the vicinity of these acute lesions, some endothelial cells were normal and some were destructive; interstitial tissues were edematous; lamellar inclusion bodies vacuolated in type II alveolar epithelial cells. After 1 w., the most striking change was the proliferation of type II cells. Moreover, the vacuolation or the disappearance of lamellar inclusion bodies was found in type II cells. These changes of lamellar inclusion bodies may lead to decrease the surfac-tant activities on alveolar walls.

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