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History of Non-Helicobacter pylori Helicobacter:Diagnosis, Epidemiology, Genetics, and Zoonosis Masahiko Nakamura 1 , Shinichi Takahashi 2 , Takeshi Matsuhisa 3 , Yoshio Yamaoka 4 , Hidenori Matsui 5 , Somay Y Murayama 6 , Hidekazu Suzuki 7 1Tokai University, School of Medicine, Isehara, Japan 2School of Medicine, Kyorin University, Tokyo 3Department of Gastroenterology, St. Marianna Medical University Toyoko Hospital, Kawasaki, Japan 4Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan 5Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo 6Department of Fungal Infection, National Institute of Infectious Diseases, Tokyo 7Department of Gastroenterology, Tokai University, School of Medicine, Isehara, Japan Keyword: Non-Helicobacter pylori Helicobacter , 歴史 , 罹患率 , 疾患 , 自然宿主 pp.13-26
Published Date 2023/1/25
DOI https://doi.org/10.11477/mf.1403203086
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 The investigation of NHPH(Non-Helicobacter pylori Helicobacter)is presumably behind H. pylori due to difficult diagnosis, including via the culture method. Research history of Helicobacter revealed that early animal studies included NHPH although they could not be identified. Furthermore, numerous case reports have accumulated and revealed the relationship between NHPH and chronic gastritis, nodular gastritis, gastric mucosa−associated lymphoid tissue lymphoma, etc., since the reports by McNulty, Dent, and Heilmann in the 1980s. Moreover, precise NHPH species classification and pathogenetic factor identification become gradually possible, which are expected to reveal the actual clinical significance of NHPH in comparison with H. pylori.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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