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Histopathology of Gastric Non-Helicobacter pylori Helicobacters and Associated Gastritis Hiroyoshi Ota 1 , Kazuki Horiuchi 2 , Tatsuya Negishi 2 , Yugo Iwaya 3 , Tadanobu Nagaya 4 1Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine, Matsumoto, Japan 2Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan 3Department of Advanced Therapeutic Endoscopy, Shinshu University School of Medicine, Matsumoto, Japan 4Department of Endoscopic Examination Center, Shinshu University Hospital, Matsumoto, Japan Keyword: Non-H. pylori Helicobacter , NHPH , 慢性胃炎 , 病理組織学的所見 , 免疫組織化学染色 pp.27-35
Published Date 2023/1/25
DOI https://doi.org/10.11477/mf.1403203088
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 NHPH(Non-Helicobacter pylori Helicobacters)infect the human gastric mucosa and are associated with gastritis, gastroduodenal ulcers, and gastric mucosa-associated lymphoid tissue lymphoma. NHPH are “tightly spiral shaped bacteria(corkscrew shape)” and have a predominantly straight appearance with large size of 4−10μM. They are readily distinguished from H. pylori(Helicobacter pylori)in Giemsa-stained sections. Immunostaining with anti- H. pylori antibodies also often reveal reactivity with NHPH. The gastric antrum is predominantly colonized by NHPH found in the mucous gel, both in the gastric foveolar lumen and on the mucosal surface, without adhesion to epithelial cells. Further, they are sometimes observed within the parietal cells. The distinctive histologic features of NHPH-associated chronic gastritis are as follows:antrum-predominant gastritis, absence of epithelial damage, mild-to-moderate mononuclear infiltration, slight and focal neutrophil infiltration, lymphocyte exudation into gastric foveolae, sizable lymphoid follicle with a germinal center, and infrequent intestinal metaplasia.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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