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Two Cases of Non-Helicobacter pylori Helicobacter Gastritis Koji Ikegami 1 , Koichi Kurahara 1 , Yumi Ohshiro 2 , Shohei Uraoka 1,3 , Ryosuke Kiyomori 1 , Yuichi Hara 1 , Shinjiro Egashira 1 , Ryutaro Mizue 1 , Yoko Minamikawa 1 , Yushi Tanaka 1 , Masahiko Nakamura 4 1Division of Gastroenterology Matsuyama Red-cross Hospital, Matsuyama, Japan 2Department of Pathology, Matsuyama Red-cross Hospital, Matsuyama, Japan 3Uraoka Ichou Clinic, Matsuyama, Japan 4Tokai University School of Medicine, Isehara, Japan Keyword: Non-Helicobacter pylori Helicobacter , HNHP , 胃炎 , H. heilmannii , H. heilmannii sensu stricto , H. suis , PCR pp.71-77
Published Date 2023/1/25
DOI https://doi.org/10.11477/mf.1403203093
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 This study reports two cases of gastritis:H. suis(Helicobacter suis)gastritis, which is considered a typical case of NHPH(Non-Helicobacter pylori Helicobacter)gastritis(case 1) ; and acute gastritis caused by H. heilmannii s.s.(Helicobacter heilmannii sensu stricto), which is very rarely reported(case 2). Case 1 was presented in a man in his 40s. H. pylori(Helicobacter pylori)serum IgG antibody and urea breath test were weakly positive for the patient, whereas stool antigen test was negative. Upper gastrointestinal endoscopy revealed a small bulge in the gastric antecubital area that was surrounded by cracked mucosa. NHPH gastritis was observed in the biopsy. The patient was diagnosed as H. suis positive on the basis of PCR(polymerase chain reaction)test. Case 2 was presented in a man in his 70s with a history of orbital pain since 2 weeks. Upper gastrointestinal endoscopy revealed erythematous edematous mucosa with firm yellowish mucus and multiple small ulcers in the gastric antecubital area. Biopsy analysis showed a helical organism larger than H. pylori, and PCR result was positive for H. heilmannii s.s. The patient was prescribed oral doses of nizatidine, leading to rapid improvement of the symptoms. Upper gastrointestinal endoscopy and biopsy performed after 3 weeks confirmed the improvement in gastritis and disappearance of organism, respectively.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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