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要旨●NHPH胃炎として典型例と考えられるH. suis胃炎の1例と,極めてまれなH. heilmannii sensu strictoによる急性胃炎の1例を経験したので報告する.[症例1]は40歳代,男性.検診の胃X線造影像で胃前庭部に隆起性病変を指摘され受診となった.H. pylori血清IgG抗体と尿素呼気試験は弱陽性,便中抗原は陰性であった.EGDで胃前庭部に小隆起を認め,その周囲にひび割れ状粘膜を認めた.生検でNHPH胃炎が疑われ,PCRにてH. suis陽性と診断された.H. pylori一次除菌に準じた治療を施行した.[症例2]は70歳代,男性.2週間続く心窩部痛があり,EGDで胃前庭部に強固な黄色調粘液付着を伴う発赤浮腫状粘膜と多発小潰瘍を認めた.生検にてH. pyloriより大型の螺旋状菌体を認め,PCRでH. heilmannii sensu stricto陽性と診断された.ニザチジン内服で症状は速やかに改善し,3週間後のEGDで胃炎所見の改善,生検で菌体の消失を確認した.
This study reports two cases of gastritis:H. suis(Helicobacter suis)gastritis, which is considered a typical case of NHPH(Non-Helicobacter pylori Helicobacter)gastritis(case 1) ; and acute gastritis caused by H. heilmannii s.s.(Helicobacter heilmannii sensu stricto), which is very rarely reported(case 2). Case 1 was presented in a man in his 40s. H. pylori(Helicobacter pylori)serum IgG antibody and urea breath test were weakly positive for the patient, whereas stool antigen test was negative. Upper gastrointestinal endoscopy revealed a small bulge in the gastric antecubital area that was surrounded by cracked mucosa. NHPH gastritis was observed in the biopsy. The patient was diagnosed as H. suis positive on the basis of PCR(polymerase chain reaction)test. Case 2 was presented in a man in his 70s with a history of orbital pain since 2 weeks. Upper gastrointestinal endoscopy revealed erythematous edematous mucosa with firm yellowish mucus and multiple small ulcers in the gastric antecubital area. Biopsy analysis showed a helical organism larger than H. pylori, and PCR result was positive for H. heilmannii s.s. The patient was prescribed oral doses of nizatidine, leading to rapid improvement of the symptoms. Upper gastrointestinal endoscopy and biopsy performed after 3 weeks confirmed the improvement in gastritis and disappearance of organism, respectively.
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