Pathological Characteristics of Adenocarcinoma of the Gastroesophageal Junction Tomio Arai 1,2 , Yoko Matsuda 1 , Hideki Hamayasu 3 , Atsuko Seki 1 , Keisuke Nonaka 1 , Junko Aida 2 , Kaiyo Takubo 2 , Makoto Nishimura 4,5 1Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo 2Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 3Department of Pathology, Matsunami General Hospital, Gifu, Japan 4Departments of Endoscopy, Tokyo Metropolitan Geriatric Hospital, Tokyo 5Gastroenterology, Tokyo Metropolitan Geriatric Hospital, Tokyo Keyword: gastroesophageal junction , adenocarcinoma , Barrett esophagus , cardiac mucosa pp.1109-1117
Published Date 2015/8/25
DOI https://doi.org/10.11477/mf.1403200380
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 Adenocarcinoma of the EGJ(esophagogastric junction)is defined as a tumor wherein the center of the tumor is located between 2cm above and 2cm below EGJ. These tumors are not uniform neoplasms but are composed of gastric cardiac adenocarcinoma and adenocarcinoma of Barrett's esophagus, particularly short-segment Barrett's esophagus. The identification of EGJ and gastric or esophageal mucosa as a background mucosa is the most important diagnostic criterion. To diagnose the esophageal origin of the tumor, the following criteria are pathognomonic : the esophageal gland proper and its duct, squamous islands, palisade vessels measuring more than 100μm in the lamina propria, and double muscularis mucosae. These features can be observed in almost all patients with Barrett's adenocarcinoma, even in endoscopically resected specimens. Several years have passed since EGJ cancer was clearly defined. To further clarify the clinicopathologic features of EGJ cancer, we need to collect further specimens of EGJ tumors to assist its correct diagnosis in future.

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