エベロリムスによる大腸炎，大腸潰瘍の1例

Everolimus induced Colitis and Ulcers, Report of a Case

要旨●患者は40歳代後半，女性．ホルモン療法耐性の進行再発乳癌に対してmTOR阻害薬エベロリムスを投与した．投与後7日目から両側腋窩，鼠径部，口周囲に紅色丘疹を認め，14日目より高熱と水様下痢を認めた．大腸内視鏡では直腸下部からS状結腸にかけて発赤，浮腫状の粘膜を背景に，縦列する多発潰瘍を認め，下行結腸では一部に縦走潰瘍を認めた．エベロリムスによる薬剤性大腸炎，大腸潰瘍と診断し，ステロイド治療を開始したところ，速やかに臨床症状および内視鏡所見の改善を認めた．

　A 49-year-old woman was treated with everolimus for recurrent hormone therapy-resistant breast cancer. She was admitted to our hospital with complaints of red papules on day 7 and diarrhea with high fever on day 14 after everolimus therapy initiation. Colonoscopy revealed an edematous reddish mucosa and multiple longitudinal ulcers in the region between the rectum and the descending colon. Thus, a diagnosis of everolimus-induced colitis and ulceration was established. Prednisolone sodium succinate administration resulted in immediate symptom alleviation and normal endoscopic findings.