Stomach and Intestine(Tokyo) Volume 54, Issue 12 (November 2019)
Japanese

Human Papillomavirus Infection in Pharyngeal and Esophageal Cancer Ken Sasaki 1 , Junichiro Ohori 2 , Fumisato Sasaki 3 , Keiichi Miyashita 2 , Itaru Omoto 1 , Masahiro Noda 1 , Yasuto Uchikado 1 , Shoji Natsugoe 1 1Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan 2Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan 3Department of Digestive and Lifestyle Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan Keyword: ヒト乳頭腫ウイルス , HPV , 頭頸部癌 , 咽頭癌 , 食道癌 pp.1663-1665
Published Date 2019/11/25
DOI https://doi.org/10.11477/mf.1403201891
  • Abstract
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 Conventionally, alcohol consumption and smoking are the main risk factors for head and neck cancers. HPV(human papillomavirus)has also been established as a cause of head and neck cancers, particularly oropharyngeal cancer. Recently, the incidence rate of HPV-positive head and neck cancers is rising rapidly. Oncogenes derived from HPV are known to inactivate the major tumor suppressors, p53 and pRB. Additionally, the epidemiologic and biological features between HPV-positive and HPV-negative oropharyngeal cancer differ completely. Therefore, novel treatment strategies for head and neck cancers should be designed according to their HPV-positive and HPV-negative statuses.


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基本情報

05362180.54.12.jpg
胃と腸
54巻12号 (2019年11月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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