Stomach and Intestine(Tokyo) Volume 54, Issue 4 (April 2019)

Celiac Disease Teruyuki Takeda 1 , Fumihito Hirai 1 , Noritaka Takatsu 1 , Masahiro Kishi 2 , Tsuyoshi Beppu 2 , Takashi Hisabe 2 , Masaki Miyaoka 3 , Kenshi Yao 3 , Ken Kinjo 4 , Atsuko Ota 4 , Hiroshi Tanabe 4 , Seiji Haraoka 4 , Akinori Iwashita 4 , Takashi Nagahama 5 , Toshiharu Ueki 2 1Inflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Chikushino, Japan 2Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan 3Department of Endoscopy, Fukuoka University Chikushi Hospital, Chikushino, Japan 4Department of Pathology, Fukuoka University Chikushi Hospital, Chikushino, Japan 5Nagahama Clinic, Fukuoka, Japan Keyword: セリアック病 , 絨毛萎縮 , 内視鏡 , 病理組織学的所見 , 鑑別疾患 pp.515-525
Published Date 2019/4/25
  • Abstract
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 Celiac disease, an autoimmune enteropathy, is caused by oral ingestion of gluten. Although rare in Japan, celiac disease merits elucidation as one of the diseases causing villous atrophy. The typical endoscopic findings of celiac disease are mosaic-patterned mucosa, deep mucosal grooves, scalloping, nodular mucosa, decline or loss of folds, visible submucosal vessel on a background of fold loss, and multiple erosions in the duodenum or small intestine. Pathological examination is imperative for definitive diagnosis, characterized by villous atrophy and elevated lymphoplasmacytic infiltration in the lamina propria. In addition, flattening, blunting, or absence in the degree of villous atrophy is assessed by the Marsh classification. This study aims to illustrate representative images and pathological findings of celiac disease with other differential diseases causing villous atrophy.

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54巻4号 (2019年4月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院