Clinical and Pathological Characteristics and Screening of Nonspecific Multiple Ulcers of the Small Intestine and Chronic Enteropathy Associated with SLCO2A1 Gene(CEAS) Hiroshi Tanabe 1 , Akinori Iwashita 1 1Department of Pathology, Fukuoka University Chikushi Hospital, Chikushino, Japan Keyword: 非特異性多発性小腸潰瘍症 , CEAS , curved ulcer pp.1431-1439
Published Date 2017/10/25
DOI https://doi.org/10.11477/mf.1403201193
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 We collated data from 46 reports in Japan involving 62 patients with nonspecific multiple ulcers of the small intestine(including our patients)and reconfirmed the clinical and pathological characteristics of these nonspecific multiple ulcers. The average age of the patients at the time of diagnosis was 39.3 years, and although the estimated average age at the time of onset was 22.5 years, a late onset age of ≧50 years was also suspected in some patients. There were more female patients than male patients(male:female ratio, 23:39), four pairs of sisters(eight patients), and 10 patients whose parents had married their cousins. Both anemia and hypoproteinemia were observed in 90% of the patients, which appear to be a significant diagnostic finding for this condition along with the presence of occult blood in feces. Many patients also don't have lesson in the terminal ileum. Regarding the shape of the ulcer, the ulcer was ring-shaped, circular, oblique, horizontal, belt-shaped, or circumferential in 79.3% of the patients and stenosis was observed in 81.0% of the patients. A majority of patients had shallow ulceration of up to UI-II, and there was a tendency for the width of the ulcer to be wider on the antimesenteric side among our patients. Twelve patients mostly satisfied the above clinical criteria and also exhibited a curved ulcer that is characteristic of this condition.

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