Immunohistochemical Stains for Colorectal Epithelial Neoplasia Yoichi Ajioka 1 1Division of Molecular and Diagnostic Pathology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan Keyword: 大腸上皮性腫瘍 , 免疫染色 , Ki-67染色 , p53染色 , ムチンコア蛋白 pp.1010-1018
Published Date 2017/7/25
DOI https://doi.org/10.11477/mf.1403201124
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 Standard immunostains used for detecting colorectal epithelial neoplasia were reviewed according to their purpose. 1)Pathological diagnosis: Ki-67 and p53 stains have a diagnostic significance. However, notably, the overexpression of p53 protein can show a strong and continuous staining pattern, whereas p53 genetic alterations can show negative staining. 2)Estimation of cancer genetic pathway: Immunostains for mismatch repair proteins may prove the development of colorectal carcinoma in the MSI(microsatellite instability)pathway. 3)Mucin phenotype classification: Based on the combination of immunostains for mucin core proteins and CD10, colorectal epithelial neoplasia can be classified into intestinal(large and small intestinal), gastric, and gastrointestinal types. This classification can be used in the estimation of cancer histogenesis and malignant potential. 4)Pathological diagnosis of UC-related intramucosal neoplasia: Ki-67 and p53 stains are necessary for accurate diagnosis. Atypical epithelium with bottom-up-type cell kinetics associated with the overexpression of p53 protein is highly speculated to indicate UC-associated neoplasia. However, the usefulness of these two stains is based on a reliable histological evaluation using the HE stain.

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