Application of Immunohistochemistry for Diagnosing Esophageal Epithelial Tumors : Immunohistochemistry for Diagnosis of Esophageal Tumor Tomio Arai 1 , Yoko Matsuda 1 , Atsuko Seki 1 , Keisuke Nonaka 1 , Mototsune Kakizaki 1 , Fukuo Kondo 2 , Junko Aida 3 , Kaiyo Takubo 3 , Toshiyuki Ishiwata 3 1Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo 2Department of Pathology, Teikyo University Hospital, Tokyo 3Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo Keyword: 食道癌 , 免疫染色 , 扁平上皮癌 , 神経内分泌細胞癌 , 癌肉腫 pp.989-996
Published Date 2017/7/25
DOI https://doi.org/10.11477/mf.1403201122
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 Pathological diagnosis of esophageal epithelial tumors is based on the observation of the tumor's histological morphology using hematoxylin-eosin staining. However, IHC(immunohistochemistry)has often been used for the differential diagnosis of the tumor. The significance of IHC performed on biopsy specimens differs from that of IHC performed on resected specimens. In a biopsy specimen, it is very important to assess whether the lesion is malignant. In addition, IHC is useful for the differential diagnosis of the histological subtypes of the tumor, such as squamous cell carcinoma, neuroendocrine carcinoma, carcinosarcoma, basaloid squamous carcinoma, adenoid cystic carcinoma, and malignant melanoma. In a resected specimen, IHC is preferentially performed for the diagnosis of the histological subtypes of the tumor, depth of tumor invasion, and vessel invasion. In particular, IHC should be performed to examine endoscopically resected specimens to determine additional treatment.

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