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Skin Lesions Induced by Anti-TNF-α Agents in Patients with Inflammatory Bowel Disease Shiro Nakamura 1 , Kazutoshi Hori 1 , Nobuyuki Hida 1 , Masaki Iimuro 1 , Takako Miyazaki 1 , Yoko Yokoyama 1 , Tetsuya Takagawa 1 , Koji Kamikozuru 1 , Mikio Kawai 1 , Yuko Kita 1 , Toshiyuki Sato 1 , Akihiro Nishio 1 , Masaru Natsuaki 2 1Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan 2Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan Keyword: 抗TNF-α抗体製剤 , Crohn病 , 潰瘍性大腸炎 , 皮膚病変 , 逆説的副反応 pp.1062-1068
Published Date 2016/7/25
DOI https://doi.org/10.11477/mf.1403200689
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 We examined the incidence of dermatologic adverse effects in 1,189 patients with inflammatory bowel disease(Crohn's disease, n=853 ; ulcerative colitis, n=336)treated with anti-TNF-α antibody preparations at our hospital between January 2009 and October 2015. Marked skin lesions were observed in 49 patients(4.1%). The incidence of adverse effects, including patients with exclusively cutaneous symptoms such as itchiness, was relatively high at 17.0%. Eczema and rash were the most commonly observed skin lesions, followed by erythema, pyoderma, asteatotic dermatitis, and herpes zoster. Psoriasis-like eruptions, a so-called paradoxical side effect, were observed in 6 patients(0.5%), a lower rate than that reported in previous overseas studies. The rate of antibody treatment discontinuation due to skin lesions was 1.4%, with approximately 50% of patients who developed skin lesions able to continue antibody treatment with the combined use of local therapy such as ointments.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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