Japanese

The Rare Disease for which Remembrance is Difficult:Familial Mediterranean Fever which Appeared by Enteritis, Report of a Case Shojiro Yamamoto 1 , Tadashi Miike 1 , Yuko Noda 1 , Takaho Noda 1 , Sho Suzuki 1 , Natsumi Uehara 1 , Sachiko Takeda 1 , Shuichiro Natsuda 1 , Mai Sakaguchi 1 , Kanna Hashimoto 1 , Kousuke Maemura 1 , Takumi Yamaji 1 , Hiroo Abe 1 , Yoshihiro Tahara 1 , Kenji Yorita 2 , Kazuya Shimoda 1 1Division of Gastroenterology and Hematology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan 2Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan Keyword: 家族性地中海熱 , 腸管病変 , 下痢 , コルヒチン pp.943-949
Published Date 2015/6/25
DOI https://doi.org/10.11477/mf.1403200350
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 A Japanese man in his 20s visited our department because of diarrhea and hematochezia. Colonoscopy revealed an inflamed granular mucosa with redness and edema in the large intestine from the cecum to the middle sigmoid colon, suggestive of ulcerative colitis. He was treated with mesalazine, and soon after, he developed pancreatitis. The treatment was changed to an antiflatulent, but it did not improve his diarrhea. After six months, he developed a fever of ≧39℃ and arthralgia. These symptoms appeared at intervals of about 2〜12 weeks and resolved spontaneously within a few days. Based on the clinical findings, we diagnosed him with familial mediterranean fever(FMF). Treatment with colchicine was very effective, and most symptoms disappeared. Diarrhea is rare as the initial symptom of FMF.


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