The 50-year History and Prospects for Diagnostic Pathology of Early Gastrointestinal Carcinomas Hidenobu Watanabe 1 1PLC Japan, Pathology & Cytology Center, Tokyo Keyword: 消化管早期癌 , 50年の歴史 , 病理診断学 , 癌診断基準 , 分化型癌の細胞異型度 pp.53-68
Published Date 2015/1/25
DOI https://doi.org/10.11477/mf.1403200132
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 Japan has been a top runner in diagnosis, therapy and research of early gastrointestinal carcinoma of the world for the past 50 years, and still progressing with sharing the results and introducing (adopting)different foreign thinking ways. Especially, the endoscopic diagnosis and therapy have outstandingly advanced in giving the happiness to the patients of the world. With the endoscopic progression, the pathology on early gastrointestinal carcinomas also has been advancing in the past 50 years. That is, the pathology was in an early stage conventional histopathology mainly using hematoxylin-eosin stain, then immuno-histochemical pathology, and now has changed to diagnostic and therapeutic histopathology suggesting the choices on therapy and predicting patients' prognosis. In this article, I will make some general remarks upon representative results about early esophageal, gastric and colonic carcinomas in the past 50 years as follows; (1)Definition and its history, (2)Macroscopic classification and its changes, (3)Difference in definition of intramucosal non-invasive carcinoma (adenocarcinoma vs. dysplasia or intraepithelial neoplastic)between Japan and the West, and (4)Importance of cytologically dividing well-differentiated type adenocarcinomas into low- and high-grade atypia.

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