雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Histogenesis of Cancer in the Upper Segment of the Stomach Kyoichi Nakamura 1 1Dept. of Pathology, Cancer Institute Hospital pp.1111-1119
Published Date 1970/8/25
DOI https://doi.org/10.11477/mf.1403111341
  • Abstract
  • Look Inside

 Histogenesis of cancer in the upper segment of the stomach has been investigated by defining it as the cardiac half of the stomach mostly formed by the mucosa of the fundic glands. The subjects of this study are 279 cases of gastric resection most of which have been histologically examined, including 220 cases of gastric cancer. The majority of these cases show early phase in development.

 In order to assume the relationship between histological types of cancer grown up to certain dimensions and the condition of the mucosa at the time of its development, tendency of changes of the gastric mucosa including age must he grasped since the gastric mucosa is not stationary.

 In the study of 279 cases in these changes of the intermediate zone and of the grade of intestinal metaplasia, the following conclusion has been drawn : Generally speaking, the irreversible shifting of the intermediate zone takes place as the age advances and the rate of intestinal metaplasia becomes accordingly more severe.

 Taking this mucosal vicissitude into consideration, we have investigated cancer of the stomach located in its upper segment. It was found as a result that cancer lesions in 22 cases were encircled all around by the mucosa of the fundic glands, and belonged histologically all to undifferentiated cancer (mucocellulare and scirrhus adenocarcinomas). Since the shifting of the intermediate zone is irreversible and intestinalized epitheliums scarcely present in the fundic glands mucosa, it can be assumed that the mucosa at the site of cancer lesion was still that of the fundic glands at the time of cancer development in these 22 cases. In other words, because the fundic glands together with the pyloric ones belong to the mucosa proper to the stomach, cancers of the undifferentiated type arise from the proper mucosa of the stomach.

 Meanwhile, there were 7 cases of cancer lesions in the upper gastric segment that were away from the intermediate zone and situated in the intestinalized mucosa. They were all differentiated cancer (tubular and papillotubular adenocarcinomas).

 Histogenesis of cancer in the upper segment of the stomach is also compatible with our concept of cancer genesis elsewhere already reported.


Copyright © 1970, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有