Early Carcinoma and Dysplasia of the Esophagus Histogenesis and Histological Diagnostic Criteria Based on Follow-up Biopsy Specimens Yasuo Ohkura 1 , Kyoichi Nakamura 2 , Tozo Hosoi 3 , Mamoru Nishizawa 3 1Department of Pathology, Tokyo Metropolitan Cancer Detection Center 2The First Department of Pathology, School of Medicine Tokyo Medical and Dental University 3Department of Gastroenterology, Tokyo Metropolitan Cancer Detection Center Keyword: 早期食道癌 , 経過観察例 , dysplasia , 生検組織診断基準 , 癌組織発生 pp.141-152
Published Date 1991/2/25
DOI https://doi.org/10.11477/mf.1403102452
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 Forty superficial carcinomas of the esophagus (10intraepithelial and 14 intramucosal carcinoma, and 16 carcinomas infiltrating in the submucosa) and 205 biopsy specimens taken from these cases were histologically studied on the relationship between carcinoma and dysplasia.

 Conclusions obtained are as follows:  1) Most of superficial carcinomas of the esophagus exhibited mosaic pattern of carcinomatous epithelium, the border of which was not distinct. Dysplastic lesions were infrequently seen in these mosaic areas.

 2) When checked with surgical specimens, many biopsy specimens originally diagnosed as dysplasia turned out to be carcinoma.

 3) Thus, the majority of squamous carcinoma of the esophagus were considered to arise directly from the squamous epithelium.

 4) The following histological findings were important in diagnosing carcinoma based on biopsy specimen: Enlargement of nucleus, irregular shape and size of the nucleus, increase in nucleocytoplasmic ratio, irregular arrangement of the basal cell layer, and downward papillary growth of the atypical squamous epithelium. Tear drop-like downward growth was suggestive of carcinoma infiltrating in the mucosa. Atypical squamous epithelium showing fusocellular pattern was also highly suggestive of malignancy.

Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.


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