Cytoprotection―A Morphological Point of View Kenzo Kobayashi 1 , Tetsuo Arakawa 1 , Hiroaki Yamada 1 , Hajime Nakamura 1 1The Third Department of Internal Medicine, Osaka City University, Medical School pp.1189-1197
Published Date 1986/11/25
DOI https://doi.org/10.11477/mf.1403110114
  • Abstract
  • Look Inside

 It is well known that cytoprotection is regarded as an action for the prevention of gastric mucosal lesions brought about by necrotizing agents capable of inducing lesions even if gastric acid is absent. Among such agents, prostaglandin (PG) is a most important substance.

 Cytoprotection should be clearly distinguished from antiulcer action in which antacid or H2 Mocker antagonists are evident. Evaluation of cytoprotection should be defined on the basis of macroscopic findings in addition to histological findings available through scanning electron-microscopy.

 A total of 24 healthy adult men aged 19-37 years, were enrolled in an at-random, placebo-controlled, parallel-group study. In these subjects, solutions of 70% ethanol (20 ml) were instilled into the posterior wall side of the antral region. OU-1308 and teprenone prevent to a great extent, ethanol induced gastric lesions. From these results, it seems that the phenomenon of cytoprotection should be recognized not only in animal models but also in humans.

Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院