Giant Eosinophilic Granuloma with Unusual Morphological Feature, Report of a Case Masaru Ishibashi 1 , Kazuo Mizushima 1 , Kazumichi Harada 1 , Ayako Naka 2 1The Third Department of Internal Medicine, Asahikawa Medical College 2Kin-ikyo Chuo Hospital pp.541-547
Published Date 1985/5/25
DOI https://doi.org/10.11477/mf.1403109847
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 The patient was a 41year-old woman with a chief complaint of nausea. Upper gastrointestinal series disclosed a huge protruded lesion in the antrum and endoscopic examination showed a submucosal mass with smooth surface and a small superficial ulceration. The mass had broad base but its head was movable and a part of the tumor was moving in and out between the antrum and the duodenal bulb. She was diagnosed to have malignant lymphoma pre-operatively and an operation was performed. Macroscopic findings of the resected specimen revealed a huge gyrus-like protruded lesion, measuring 10×10cm. The lesion found to be pedunculated when it was lifted-up and a stalk measuring 5 cm was noted on the gastric mucosal fold. Shallow ulceration was also noted partly.

 Its cut surface disclosed hypertrophy mainly in the submucosa along the enlarged gastric folds. Histological examination showed proliferation of fibrous connective tissue and proliferation fibroblasts from the mucosal base and the submucosal area. The fibrous tissue had fine fibers with coil arrangement suggesting nerve fibers but hyalinization was not detected. There was massive eosinophilic infiltration in the tissue and histologically, it was a typical case of eosinophilic granuloma of the stomach.

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