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Acute Esophageal Ulcers Associated with Doxycycline Therapy, Report of Two Cases Katsuaki Tanaka 1 , Ryoichi Suzuki 1 , Katsuro Nishigori 1 , Tatsuo Sugimasa 1 , Yutaro Takamura 1 1The Third Department of Internal Medicine, Yokohama City University, School of Medicine pp.549-553
Published Date 1985/5/25
DOI https://doi.org/10.11477/mf.1403109851
  • Abstract
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 Two cases of doxycydine tablet-induced esophageal ulcer are presented with special reference to their endoscopic characteristics. As to the patient's history, it was very characteristic that they took a tablet just before lying in bed, with no or only small amount of water. Clinical symptom was dysphagia and the symptom appeared soon after taking the drug. The diagnosis was fairly easy because of the characteristic history and the relationship to the drug.

 Endoscopic examination confirmed fresh ulcers in two cases. In the first case, taking a doxycycline tablet caused a single ulcer with the edematous margin, irregular in shape, and in the second case, a doxycycline tablet caused multiple ulcers, round in shape. This discrepancy might be closely related to the lodging time of a tablet to the esophageal mucosa.


Copyright © 1985, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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