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Staining Property of Human Colonic Mucin by Periodic Acid-Thionin Schiff/Potassium Hydroxide/Periodic Acid-Schiff (PAT/KOH/PAS) Method T. Muto 1 1Department of Surgery, Faculty of Medicine, University of Tokyo pp.343-348
Published Date 1982/3/25
DOI https://doi.org/10.11477/mf.1403108823
  • Abstract
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 A large number of colonic disease together with surrounding mucosa were stained by Culling's PAT/KOH/PAS method and staining property of human colonic mucin was investigated. All advanced carcinomas were stained purple or blue indicating abnormal mucin as suggested by Culling et al. Although the surrounding mucosa of colonic carcinoma was stained in purple or blue in 64%, there was no statistical difference as compared to the control which had no disease throughout the colon. Tubular adenomas were stained in red or purple but villous and tubulo-villous adenomas stained in purple or blue quite frequently. The background mucosa of adenomatosis coli was stained in purple or blue in 92% with statistical significance, suggesting the possible value of this staining method in early detection of the carrier of this hereditary disease. Since dysplastic tubules in ulcerative colitis showed abnormal staining, this method could be useful in the diagnosis of premalignant change in ulcerative colitis.

 Problems and value of this mucin staining method at present time were briefly discussed.


Copyright © 1982, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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